ONJ - although some Fosamax side effects can some times develop themselves in an extreme problem, the most dangerous Fosamax side effect is the development of a bone disease called necrosis of the jaw necrosis of the jaw is a certain kind of bone disease that is most often associated with the larger joints of the body such as the the knees, hips, ankles or shoulders. The first stage of ONJ is tied to the temporary or long term loss of blood to the bone tissue, which leads to death of the tissue and eventually collapsing of the bone.
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